3-(1H-Imidazol-2-yl)pyridine → 3-(1H-imidazol-2-yl)piperidine

HRID 364722ノート

反応式

HRID 364722 の反応式
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:7]=[N:8][CH:9]=[CH:10][CH:11]=1.[H][H]>C(O)C.[Pt]=O>[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]1[CH2:11][CH2:10][CH2:9][NH:8][CH2:7]1

参加物

5

反応物 2

HCID 123955003-(1H-Imidazol-2-yl)pyridineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 132811953-(1H-imidazol-2-yl)piperidine収率 108%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒

実験手順

3-(1H-imidazol-2-yl)pyridine (4.0 g, 0.0275M) and platinum oxide (0.5 g) in ethyl alcohol (50 ml) and 1NHCl (50 ml) was reduced at 45 psig of hydrogen for 4 hrs. The reaction mixture was filtered and the filtrate was stripped to dryness and crystallized from MeOH-EtOH to give 3-(1H-imidazol-2-yl)piperidine (4.5 g, 74% yield, mp 295° dec.).

後処理

  1. filtrationThe reaction mixture was filtered
  2. customcrystallized from MeOH-EtOH

出典と根拠

ORDレコード
ord-da504b5de72644938bcd1b7632698fa1
出典データセット
uspto-grants-1986_08
特許番号
US04605744

反応ノート

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