HCID 13281197、化合物 → 4-(1h-Imidazol-2-ylmethyl)piperidine

HRID 364729ノート

反応式

HRID 364729 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]2[NH:9][CH:10]=[CH:11][N:12]=2)=[CH:3][CH:2]=1.O(C)[Na]>CO>[NH:9]1[CH:10]=[CH:11][N:12]=[C:8]1[CH2:7][CH:4]1[CH2:5][CH2:6][NH:1][CH2:2][CH2:3]1

参加物

4

反応物 2

HCID 13281197HCID 13281197、化合物HCID 178418582HCID 178418582、化合物

生成物 1

HCID 132811984-(1h-Imidazol-2-ylmethyl)piperidine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-(4-pyridylmethyl)imidazole (4 g, 0.025M) and platinum oxide (0.4 g) in ethanol (40 ml) and 2NHCl (50 ml) was hydrogenated at 45 psig for 4 hrs. The catalyst was removed by filtration and the filtrate was stripped to dryness. Crystallization from ethanol gave 4-(1H-imidazol-2-yl-methyl)piperidine as the dihydrochloride salt m.p. 251°-252° C. (5.2 g, 87% yield). The mixture of 2-(4-pyridylmethyl)-imidazole (2.38 g, 10 mM) and NaOCH3 (10 mM) in methanol (20 ml) was stirred for 10 min. and filtered. The filtrate was stripped to dryness and distilled from about 180° to about 200° C./0.3 mmHg to give the free base of 4-(1H-imidazol-2-yl-methyl)piperidine.

後処理

  1. filtrationfiltered
  2. distillationdistilled from about 180° to about 200° C./0.3 mmHg

出典と根拠

ORDレコード
ord-9a1f8cc4ecdb4641921e3ff5378c2736
出典データセット
uspto-grants-1986_08
特許番号
US04605744

反応ノート

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