Hydrochloric Acid → 4-[2-(1-Ethyl-4,5-dihydro-imidazol-2-yl)ethyl]piperidine

HRID 364735ノート

反応式

HRID 364735 の反応式
[CH2:1]([N:3]1[CH2:7][CH2:6][N:5]=[C:4]1[CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=1)[CH3:2].Cl>C(O)C.O.[Pt]=O>[CH2:1]([N:3]1[CH2:7][CH2:6][N:5]=[C:4]1[CH2:8][CH2:9][CH:10]1[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]1)[CH3:2]

参加物

6

反応物 2

HCID 313Hydrochloric AcidHCID 137267364-[2-(1-Ethyl-4,5-dihydro-imidazol-2-yl)ethyl]-pyridine

生成物 1

HCID 134731494-[2-(1-Ethyl-4,5-dihydro-imidazol-2-yl)ethyl]piperidine収率 70.6%

試薬・触媒・溶媒 3

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

The solution of 4-[2-(1-ethyl-4,5-dihydro-imidazol-2-yl)ethyl]-pyridine (1.1 g, 0.0054M) in ethanol (15 ml) and water (15 ml) was added con.HCl (3 ml) and platinum oxide (0.2 g). The mixture was hydrogenated at 45 psig for 4 hrs. The catalyst was removed by filtration and the filtrate was stripped to dryness in vacuo. The residue was dissolved in methanol (25 ml) and sodium methoxide (0.011M) was added and filtered. The filtrate was stripped to dryness and distilled at about 150° to about 175° C./0.2 mm Hg to yield 4-[2-(1-ethyl-4,5-dihydro-imdazol-2-yl)ethyl]piperidine as an oil (0.8 g, 70% yield).

後処理

  1. customThe catalyst was removed by filtration
  2. dissolutionThe residue was dissolved in methanol (25 ml)
  3. additionsodium methoxide (0.011M) was added
  4. filtrationfiltered
  5. distillationdistilled at about 150° to about 175° C./0.2 mm Hg

出典と根拠

ORDレコード
ord-0d3666a787654767a2885baddfed68b6
出典データセット
uspto-grants-1986_08
特許番号
US04605744

反応ノート

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