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Phenoxyacetyl chloride → Ethyl 4-(1-oxo-2-phenoxyethylamino)butanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenoxyacetyl chloride | HCID 69703 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 4-Aminobutyrate ethyl hydrochloride | HCID 12649661 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | Ethyl 4-(1-oxo-2-phenoxyethylamino)butanoate | HCID 53983334 | 53% |
反応手順
To a stirred mixture of ethyl 4-aminobutanoate hydrochloride (3.4 g) and phenoxyacetyl chloride (2.76 ml) in 50 ml of Et2O and 50 ml of water was added one portion of NaHCO3 (4.2 g). After 2 hr the layers were separated and the organic phase was washed (1N HCl, brine), dried (MgSO4), and filtered. Evaporation of the solvent under vacuum gave 3.1 g (53%) of the title compound as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05414132 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-98d2491207f3486cb4bc46f3b8953d73 |
| 出典メモ | uspto-grants-1995_05 |