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Propionate ion → 3-(2-Nitrophenyl)isoxazolin-5-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Propionate ion | HCID 104745 | — |
| 反応物 | Butyrate | HCID 104775 | — |
| 反応物 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | Ethyl 2-nitro-beta-oxobenzenepropanoate | HCID 10561837 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-(2-Nitrophenyl)isoxazolin-5-one | HCID 21271853 | — |
反応手順
The reactions of Equations 15a and 15b above can be run by procedures similar to those described in U.S. Pat. No. 3,781,438 for the preparation of 5-halo-3-phenylisoxazoles. Thus, in reaction 15a, an ethyl 2-(2-nitrobenzoyl)acetate, propionate or butyrate of Formula (XIV) is reacted with hydroxylamine hydrochloride and sodium acetate in ethanol at reflux for 0.5 to 5 hours to form a 3-(2-nitrophenyl)isoxazolin-5-one of Formula (XXVI). In reaction 15b, XXVI is reacted with an equimolar amount of triethylamine and excess phosphorus oxychloride or phosphorus oxybromide in toluene at 25° to 110° C. for 1 to 5 hours to form Xc"'.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04606755 |
| 出典データセット | uspto-grants-1986_08 |
| ORD ID | ord-cb8e304acedb42a3ba4e8998b434a0dc |
| 出典メモ | uspto-grants-1986_08 |