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N-(2-Acetylphenyl)acetamide → N-[2-[3-(Dimethylamino)-1-oxo-2-propenyl]phenyl]acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(2-Acetylphenyl)acetamide | HCID 21306 | — |
| 反応物 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N-[2-[3-(Dimethylamino)-1-oxo-2-propenyl]phenyl]acetamide | HCID 54331422 | 63.6% |
反応手順
A suspension of 48 g of N-[2-(1-oxo-1-ethanyl)phenyl]acetamide and 38 g of N,N-dimethylformamide dimethyl acetal in 150 ml of toluene was heated at reflux for about 16 hours, then concentrated in vacuo to a solid. The solid was recrystallized from 1-chlorobutane to yield 40 g of the title compound; m.p. 90°-95° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04606755 |
| 出典データセット | uspto-grants-1986_08 |
| ORD ID | ord-93ec883c9ccb4b28914aad0f2c2c7668 |
| 出典メモ | uspto-grants-1986_08 |