Ethanol → Ethyl 4-formylbenzoate

HRID 36488

反応式

HRID 36488 の反応式
[CH:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1)=[O:2].[CH3:12][CH2:13]O.CCOCC>ClCCCl>[CH:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([O:9][CH2:12][CH3:13])=[O:8])=[CH:5][CH:4]=1)=[O:2]

参加物

5

反応物 3

HCID 702EthanolHCID 3283Diethyl EtherHCID 120884-Formylbenzoic acid

生成物 1

HCID 80498Ethyl 4-formylbenzoate収率 68%

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

A mixture of 4-formylbenzoic acid (25 g) conc sulfuric acid (2 ml) and EtOH (19.5 ml) was refluxed gently for 5 days in 100 ml of 1,2-dichloroethane. The solvent was then stripped, and Et2O was added to the residue. The Et2O solution was washed (satd aq NaHCO3) dried (Na2SO4), filtered, and evaporated. Bulb to bulb distillation afforded 20.1 g (68%) of the title ester as a clear liquid, bp 145°-150° (2,900 Pascals, 22 torr).

後処理

  1. washThe Et2O solution was washed (satd aq NaHCO3)
  2. dry with materialdried (Na2SO4)
  3. filtrationfiltered
  4. customevaporated
  5. distillationBulb to bulb distillation

出典と根拠

ORDレコード
ord-04e21b8f0b284580b11a384d44c8297e
出典データセット
uspto-grants-1995_05
特許番号
US05414132

関連ノート

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