2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → 1-Piperazinecarboxamide, 4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-N-cyclopentyl-

HRID 364885

反応式

HRID 364885 の反応式
[N:1]1([C:7]2[N:16]=[C:15]([NH2:17])[C:14]3[C:9](=[CH:10][C:11]([O:20][CH3:21])=[C:12]([O:18][CH3:19])[CH:13]=3)[N:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH:22]1([N:27]=[C:28]=[O:29])[CH2:26][CH2:25][CH2:24][CH2:23]1>O1CCOCC1>[CH:22]1([NH:27][C:28]([N:4]2[CH2:5][CH2:6][N:1]([C:7]3[N:16]=[C:15]([NH2:17])[C:14]4[C:9](=[CH:10][C:11]([O:20][CH3:21])=[C:12]([O:18][CH3:19])[CH:13]=4)[N:8]=3)[CH2:2][CH2:3]2)=[O:29])[CH2:26][CH2:25][CH2:24][CH2:23]1

参加物

4

反応物 2

HCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazolineHCID 643500Cyclopentyl Isocyanate

生成物 1

HCID 1572951-Piperazinecarboxamide, 4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-N-cyclopentyl-収率 83.6%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

In 30 ml of dioxane, there was dissolved 1.16 g. (4 mmole) of 2-piperazino-4-amino-6,7-dimethoxyquinazoline. To the resultant solution was added dropwise 0.45 g. (4 mmole) of cyclopentyl isocyanate at room temperature and the mixture was stirred overnight at room temperature. The precipitated crystals were recovered by filtration to obtain 1.34 g. of the desired product.

後処理

  1. filtrationThe precipitated crystals were recovered by filtration
  2. customto obtain 1.34 g

出典と根拠

ORDレコード
ord-9dffeeef4c7a473db638aaa2bc8bade2
出典データセット
uspto-grants-1986_08
特許番号
US04607034

関連ノート

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