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Sulfuric Acid → 2-Chloro-N-[(6-hydroxy-2,3-dihydro-1H-inden-5-yl)methyl]acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 5-Indanol | HCID 15118 | — |
| 反応物 | N-Methylol-alpha-chloroacetamide | HCID 62466 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-Chloro-N-[(6-hydroxy-2,3-dihydro-1H-inden-5-yl)methyl]acetamide | HCID 21296915 | — |
反応手順
134 g (1 mole) of 5-hydroxyindane and 100 g (0.81 mole) of 2-chloro-N-hydroxymethylacetamide are suspended in 300 ml of glacial acetic acid, and 10 ml of concentrated sulfuric acid are added. The mixture is stirred for 30 minutes at room temperature and is poured into ice water. The product is filtered off with suction and recrystallized from methanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04607030 |
| 出典データセット | uspto-grants-1986_08 |
| ORD ID | ord-ecaa98b7278c4f35a2279ce3ff24fee3 |
| 出典メモ | uspto-grants-1986_08 |