Ethylparaben → Ethyl 4-[2-Oxo-2-(phenylmethoxy)ethoxy]benzoate

HRID 36491

反応式

HRID 36491 の反応式
[OH:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][CH:3]=1.Br[CH2:14][C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.O>[O:16]=[C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:14][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:11][CH:12]=1

参加物

6

反応物 3

HCID 8434EthylparabenHCID 11430Potassium CarbonateHCID 62576Benzyl bromoacetate

生成物 1

HCID 53990693Ethyl 4-[2-Oxo-2-(phenylmethoxy)ethoxy]benzoate収率 99%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

A mixture of ethyl p-hydroxybenzoate (4.98 g), benzyl bromoacetate (4.75 ml) and K2CO3 (4.14 g) was stirred for 15 hr in 30 ml of DMF. The reaction mixture was diluted with water (200 ml) and extracted with a 1:1 ether:hexane mixture. The combined organic extracts were washed (water, brine), dried (Na2SO4), filtered, and evaporated leaving 9.3 g, (99%) of the title compound as a heavy oil; TLC, Rf =0.71, Et2O: hexane (1:1).

後処理

  1. extractionextracted with a 1:1 ether
  2. washThe combined organic extracts were washed (water, brine)
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. customevaporated

出典と根拠

ORDレコード
ord-76c44d27eb4b427882d1bb80398ab9ef
出典データセット
uspto-grants-1995_05
特許番号
US05414132

関連ノート

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