Ammonia → 6-(N-Chloroacetylaminomethyl)-5-hydroxy-4-sulfamoylindane

HRID 364910ノート

反応式

HRID 364910 の反応式
[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][CH2:13]2)=[C:9]([S:16](Cl)(=[O:18])=[O:17])[C:8]=1[OH:20])=[O:4].[NH3:21]>CC(C)=O.O>[Cl:1][CH2:2][C:3]([NH:5][CH2:6][C:7]1[CH:15]=[C:14]2[C:10]([CH2:11][CH2:12][CH2:13]2)=[C:9]([S:16](=[O:18])(=[O:17])[NH2:21])[C:8]=1[OH:20])=[O:4]

参加物

5

反応物 2

HCID 222AmmoniaHCID 212969316-(N-Chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane

生成物 1

HCID 132103556-(N-Chloroacetylaminomethyl)-5-hydroxy-4-sulfamoylindane

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 962Water溶媒

実験手順

33.8 g (0.1 mole) of 6-(N-chloroacetylaminomethyl)-5-hydroxy-4-chlorosulfonylindane are dissolved in a little acetone, and the solution is added dropwise to 50 ml of concentrated ammonia solution. The mixture is stirred for 30 minutes at room temperature and is diluted with water. The precipitate which is deposited is filtered off with suction and dissolved in acetone, and the solution is filtered and stirred into water again.

後処理

  1. filtrationThe precipitate which is deposited is filtered off with suction
  2. dissolutiondissolved in acetone
  3. filtrationthe solution is filtered
  4. stirringstirred into water again

出典と根拠

ORDレコード
ord-014011e3e98841fd98e40d5753661173
出典データセット
uspto-grants-1986_08
特許番号
US04607030

反応ノート

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