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Tetrahydro-4H-pyran-4-ol → Tetrahydro-4H-pyran-4-yl 3-oxobutanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydro-4H-pyran-4-ol | HCID 74956 | — |
| 反応物 | 5-Acetyl-2,2-dimethyl-1,3-dioxane-4,6-dione | HCID 2763470 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | Tetrahydro-4H-pyran-4-yl 3-oxobutanoate | HCID 20189394 | — |
反応手順
A solution of tetrahydro-4H-pyran-4-ol (1.6 ml, 16.8 mmoles) and 5-acetyl-2,2-dimethyl-1,3-dioxane-4,6-dione (3.0 g, 16.1 mmoles) in dry benzene (50 ml) was heated under reflux for 4 hours. The solvent was removed in vacuo and the residue distilled at 146°-151°/14 mm Hg to afford the title product as a colourless oil, 2.84 g. Nmr (CDCl3)δ5.1 (m,H), 3.5 (s,3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04607041 |
| 出典データセット | uspto-grants-1986_08 |
| ORD ID | ord-0c9e66dbb7ed47049ac887ccda7de01a |
| 出典メモ | uspto-grants-1986_08 |