L-Leucine, ethyl ester, hydrochloride (1:1) → N-(3,5-diacetamido-2,4,6-triiodobenzoyl)-L-leucine ethyl ester

HRID 365031ノート

反応式

HRID 365031 の反応式
[C:1]([NH:4][C:5]1[C:6]([I:20])=[C:7]([C:11]([I:19])=[C:12]([NH:15][C:16](=[O:18])[CH3:17])[C:13]=1[I:14])[C:8](Cl)=[O:9])(=[O:3])[CH3:2].Cl.[CH2:22]([O:24][C:25](=[O:32])[C@H:26]([CH2:28][CH:29]([CH3:31])[CH3:30])[NH2:27])[CH3:23]>>[CH2:22]([O:24][C:25](=[O:32])[C@H:26]([CH2:28][CH:29]([CH3:31])[CH3:30])[NH:27][C:8](=[O:9])[C:7]1[C:6]([I:20])=[C:5]([NH:4][C:1](=[O:3])[CH3:2])[C:13]([I:14])=[C:12]([NH:15][C:16](=[O:18])[CH3:17])[C:11]=1[I:19])[CH3:23]

参加物

3

反応物 2

HCID 11658447L-Leucine, ethyl ester, hydrochloride (1:1)HCID 160896703,5-Diacetamido-2,4,6-triiodobenzoyl chloride

生成物 1

HCID 53661440N-(3,5-diacetamido-2,4,6-triiodobenzoyl)-L-leucine ethyl ester

実験手順

Following the procedure of example 13, 48 g (64%) of this product was synthesized from 63.2 g (0.1 Mol) 3,5-diacetamido-2,4,6-triiodobenzoyl chloride and 29.4 g (0.15 Mol) L-leucine ethyl ester hydrochloride.

出典と根拠

ORDレコード
ord-42aa7b4df695444d9f915ffb3095f672
出典データセット
uspto-grants-1986_08
特許番号
US04607123

反応ノート

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