Piperidine → 2-[4-(Diethylamino)styryl]-1-hexylpyridinium bromide hemihydrate

HRID 365122

反応式

HRID 365122 の反応式
[Br-:1].[CH2:2]([N+:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH3:14])[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[CH2:15]([N:17]([CH2:26][CH3:27])[C:18]1[CH:25]=[CH:24][C:21]([CH:22]=[O:23])=[CH:20][CH:19]=1)[CH3:16].N1CCCCC1>CO>[OH2:23].[Br-:1].[CH2:26]([N:17]([CH2:15][CH3:16])[C:18]1[CH:25]=[CH:24][C:21]([CH:22]=[CH:14][C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][N+:8]=2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])=[CH:20][CH:19]=1)[CH3:27].[CH2:15]([N:17]([C:18]1[CH:19]=[CH:20][C:21]([CH:22]=[CH:14][C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][N+:8]=2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])=[CH:24][CH:25]=1)[CH2:26][CH3:27])[CH3:16].[Br-:1]

参加物

5

反応物 3

HCID 8082PiperidineHCID 671144-(Diethylamino)benzaldehydeHCID 219878661-Hexyl-2-methylpyridinium bromide

生成物 1

HCID 704553642-[4-(Diethylamino)styryl]-1-hexylpyridinium bromide hemihydrate収率 45.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1-Hexyl-2-methylpyridinium bromide (7.8 g, 0.03 mole) and 4-diethylaminobenzaldehyde (7.0 g, 0.04 mole) were refluxed in methanol (50 ml) in the presence of piperidine (1.0 ml) under nitrogen for four hours. The solution was evaporated and the resulting oil was redissolved in a small amount of isopropanol. Addition of twice the volume of ether gave a red crystalline solid which was collected and washed with isopropanol/ether to give 2-[4-(diethylamino)styryl]-1-hexylpyridinium bromide hemihydrate (5.8 g), melting point 222°-223° (decomposition).

後処理

  1. customThe solution was evaporated
  2. dissolutionthe resulting oil was redissolved in a small amount of isopropanol
  3. additionAddition of twice the volume of ether
  4. customgave a red crystalline solid which
  5. customwas collected
  6. washwashed with isopropanol/ether

出典と根拠

ORDレコード
ord-309cd08193b94334b1b909faff8e5a58
出典データセット
uspto-grants-1986_08
特許番号
US04608379

関連ノート

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