関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | 2-Methylpyridine | HCID 7975 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 4-(Diethylamino)benzaldehyde | HCID 67114 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 1-Benzyl-2-[4-(diethylamino)styryl]pyridinium bromide | HCID 70455530 | 44.4% |
反応手順
2-Picoline (9.3 g, 0.1 mole) and benzyl bromide (17.1 g, 0.1 mole) were refluxed in isopropanol (50 ml) overnight. The solvent was evaporated giving an oil which was heated at 100° C. for six hours. The resulting crude oil (8.5 g, 0.032 mole) and 4-diethylaminobenzaldehyde (6.0 g, 0.033 mole) were refluxed in methanol (40 ml) in the presence of piperidine (0.2 ml) under nitrogen for three hours. On cooling dark-coloured crystals were obtained which were collected to give 1-benzyl-2-[4-(diethylamino)styryl]pyridinium bromide (6.2 g), melting point 231°-233° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04608379 |
|---|
| 出典データセット | uspto-grants-1986_08 |
|---|
| ORD ID | ord-d040665acb754439b3780d1ccacf8331 |
|---|
| 出典メモ | uspto-grants-1986_08 |
|---|
