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1-(2-Methoxyphenyl)piperazine → 3-(4-(2-Methoxyphenyl)piperazin-1-yl)propanenitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(2-Methoxyphenyl)piperazine | HCID 1346 | — |
| 反応物 | Acrylonitrile | HCID 7855 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-(4-(2-Methoxyphenyl)piperazin-1-yl)propanenitrile | HCID 1822604 | 91.7% |
反応手順
A solution of acrylonitrile (1.06 g, 20 mmol) in ethanol (50 ml) was added to a stirred solution of 2-methoxyphenylpiperazine (3.84 g, 20 mmol) in ethanol (100 ml). After 18 h, the solvent was evaporated in vacuo to give the product (4.5 g) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06127357 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-22fea30183c04db69593e05118e5f118 |
| 出典メモ | uspto-grants-2000_10 |