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3-(4-(2-Methoxyphenyl)piperazin-1-yl)propanenitrile → 1-(3-Aminopropyl)-4-(2-methoxyphenyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(4-(2-Methoxyphenyl)piperazin-1-yl)propanenitrile | HCID 1822604 | — |
| 触媒 | Rhodium | HCID 23948 | — |
| 溶媒 | Ammonia | HCID 222 | — |
| 生成物 | 1-(3-Aminopropyl)-4-(2-methoxyphenyl)piperazine | HCID 10467259 | 86.9% |
反応手順
A solution of the product of Example 26 (4.4 g, 18 mmol) in concentrated ethanolic ammonia solution (150 ml) was hydrogenated over 5% rhodium on alumina powder (0.6 g) at 50 p.s.i. (about 3.4×105Pa) for 50 h to give the product (3.9 g) as a brown oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06127357 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-b9864ad77a494dd3a63c53c478ce0381 |
| 出典メモ | uspto-grants-2000_10 |