2-Chloropyridine → 4-(2-Methoxyphenyl)-1-(3-(pyridin-2-yl)aminopropyl)piperazine

HRID 365297

反応式

HRID 365297 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH2:18])[CH2:11][CH2:10]1.Cl[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=1>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=2)[CH2:13][CH2:14]1

参加物

4

反応物 2

HCID 79772-ChloropyridineHCID 104672591-(3-Aminopropyl)-4-(2-methoxyphenyl)piperazine

生成物 1

HCID 232909324-(2-Methoxyphenyl)-1-(3-(pyridin-2-yl)aminopropyl)piperazine収率 13.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The product of Example 27 (3.9 g, 16 mmol) and 2-chloropyridine (1.82 g, 16 mmol) were heated at 160° C. in a sealed vessel for 6 h. After cooling, the residue was taken up into CH2Cl2 (50 ml) washed with aqueous NaOH (3×50 ml), dried (MgSO4) and evaporated in vacuo. The residue was purified by chromatography [alumina; ethyl acetate-toluene (1:4)] to give the product (0.7 g) as a brown oil.

後処理

  1. temperatureAfter cooling
  2. washwashed with aqueous NaOH (3×50 ml)
  3. dry with materialdried (MgSO4)
  4. customevaporated in vacuo
  5. customThe residue was purified by chromatography [alumina; ethyl acetate-toluene (1:4)]

出典と根拠

ORDレコード
ord-44c7f45ad7ea43e1a71cb8c15e4f41e7
出典データセット
uspto-grants-2000_10
特許番号
US06127357

関連ノート

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