HCID 130039219、化合物 → HCID 53944516、化合物
反応式
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[S:13][CH2:12][CH2:11][C:10]2=[O:15])=[O:4]>C(O)C>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[S:13][CH2:12][CH2:11][CH:10]2[OH:15])=[O:4]参加物
3
実験手順
Methylthiochroman-4-one-8-carboxylate (0.500 g, 2.25 mmol) was dissolved with stirring in ethanol (20 ml). After 1 h, the reaction mixture was evaporated under reduced pressure and the residue partitioned between ethyl acetate and water. The aqueous layer was then extracted with ethyl acetate (1×) and the combined organic layers were dried (Na2SO4) and evaporated under reduced pressure to give a yellow oil, which was purified by silica-gel chromatography (1:1 Pentane:EtOAc as eluant) to give the title compound as a colourless oil (0.499 g, 99%)
後処理
- customthe reaction mixture was evaporated under reduced pressure
- customthe residue partitioned between ethyl acetate and water
- extractionThe aqueous layer was then extracted with ethyl acetate (1×)
- dry with materialthe combined organic layers were dried (Na2SO4)
- customevaporated under reduced pressure
- customto give a yellow oil, which
- customwas purified by silica-gel chromatography (1:1 Pentane:EtOAc as eluant)
出典と根拠
- ORDレコード
- ord-e541aa62f4084f87b2f3dc86832460b5
- 出典データセット
- uspto-grants-2000_10
- 特許番号
- US06127379
反応ノート
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