Bromine → HCID 23291438、化合物
反応式
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:14]=1[S:13][CH2:12][CH2:11][CH2:10]2)=[O:4].[Br:15]Br>ClCCl>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]([Br:15])[CH:8]=[C:9]2[C:14]=1[S:13][CH2:12][CH2:11][CH2:10]2)=[O:4]参加物
4
実験手順
A solution of methylthiochroman-8 carboxylate (0.300 g, 1.44 mmol) (D6a) in dichloromethane (20 ml) was treated with bromine (0.106 ml, 2.07 mmol) and the reaction mixture left at room temperature. After 4 days the reaction mixture was washed with sodium metabisulphile solution. The organic layer was then dried (Na2SO4) and evaporated under reduced pressure to give the title compound as a colourless oil (0.340 g, 82%).
後処理
- waitthe reaction mixture left at room temperature
- washAfter 4 days the reaction mixture was washed with sodium metabisulphile solution
- dry with materialThe organic layer was then dried (Na2SO4)
- customevaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-886d61cb3b0f4033b1274b1a3aa1e2be
- 出典データセット
- uspto-grants-2000_10
- 特許番号
- US06127379
反応ノート
読み込み中…