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Methanol → Pyridine-3,5-dicarboxylic acid methyl ester hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | 3,5-Pyridinedicarboxylic acid | HCID 10366 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 生成物 | Pyridine-3,5-dicarboxylic acid methyl ester hydrochloride | HCID 70274642 | — |
反応手順
Pyridine-3,5-dicarboxylic acid (5.00 g, 29.9 mmol) was stirred in CH3OH (100 mL), cooled in an ice bath, and treated dropwise with thionyl chloride (17.45 mL, 239.2 mmol). After 0.5 hr, the reaction mixture was refluxed for 48 hrs. Concentration to dryness gave the title compound as an off-white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06127366 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-1b62a4aa5e3545ef8cc070eb914f7418 |
| 出典メモ | uspto-grants-2000_10 |