Methanol → Pyridine-3,5-dicarboxylic acid methyl ester hydrochloride

HRID 365437

反応式

HRID 365437 の反応式
[N:1]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[CH:4]=[C:3]([C:10]([OH:12])=[O:11])[CH:2]=1.S(Cl)([Cl:15])=O.[CH3:17]O>>[ClH:15].[CH3:17][O:8][C:7]([C:5]1[CH:6]=[N:1][CH:2]=[C:3]([C:10]([OH:12])=[O:11])[CH:4]=1)=[O:9]

参加物

4

反応物 3

HCID 887MethanolHCID 103663,5-Pyridinedicarboxylic acidHCID 24386Thionyl Chloride

生成物 1

HCID 70274642Pyridine-3,5-dicarboxylic acid methyl ester hydrochloride

実験手順

Pyridine-3,5-dicarboxylic acid (5.00 g, 29.9 mmol) was stirred in CH3OH (100 mL), cooled in an ice bath, and treated dropwise with thionyl chloride (17.45 mL, 239.2 mmol). After 0.5 hr, the reaction mixture was refluxed for 48 hrs. Concentration to dryness gave the title compound as an off-white solid.

後処理

  1. temperaturecooled in an ice bath
  2. temperaturethe reaction mixture was refluxed for 48 hrs
  3. concentrationConcentration to dryness

出典と根拠

ORDレコード
ord-1b62a4aa5e3545ef8cc070eb914f7418
出典データセット
uspto-grants-2000_10
特許番号
US06127366

関連ノート

読み込み中…