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(S)-1-(3-Chlorophenyl)ethane-1,2-diol → (s)-(2-(3-Chlorophenyl)-2-hydroxyethyl)oxocarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (S)-1-(3-Chlorophenyl)ethane-1,2-diol | HCID 10130180 | — |
| 反応物 | (s)-(2-(3-Chlorophenyl)-2-carbamoyloxyethyl)oxocarboxamide | HCID 131721943 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (s)-(2-(3-Chlorophenyl)-2-hydroxyethyl)oxocarboxamide | HCID 131721942 | 25% |
反応手順
(S)-(2-(3-Chlorophenyl)-2-carbamoyloxyethyl)oxocarboxamide (1.36 g, yield 25%, m.p. 117-119° C., [α]D =12.88 (c=2.30, MeOH) was prepared using the same synthetic method described in Example 20, except (S)-1-m-chlorophenyl-1,2-ethanediol was used instead of (DL)-1-m-chlorophenyl-1,2-ethanediol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06127412 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-6cfca9cd125a4350a3f7dbb8723965ae |
| 出典メモ | uspto-grants-2000_10 |