関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Butene-1,4-diol | HCID 8065 | — |
| 反応物 | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| 反応物 | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| 溶媒 | Tetrahydrofurane dichloromethane | HCID 21919333 | — |
| 生成物 | (Z)-4-(Tetrahydro-2H-pyran-2-yl-oxy)but-2-en-1-ol | HCID 10975949 | 481.9% |
反応手順
Dihydropyran (9.1 ml, 100 mmol) was added dropwise to a cooled (0° C.) solution of 2-butene-1,4-diol (8.8 g, 10 mmol) and pyridinium paratoluenesulfonate (0.25 g, 10 mmol) in anhydrous dichloromethane:tetrahydrofuran (2:1). The mixture was stirred two days at 0° C. then concentrated in vacuo. The residue was purified by flash chromatography on silica gel (ethyl acetate:hexane 3:7) to give 8.3 g of the title compound (49%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05416076 |
|---|
| 出典データセット | uspto-grants-1995_05 |
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| ORD ID | ord-0deb034b167b441282245b88540d7147 |
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| 出典メモ | uspto-grants-1995_05 |
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