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3,4-dihydro-2H-pyran → Ethyl 2,2-difluoro-3-tetrahydropyranyloxypropionate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| 反応物 | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| 反応物 | Ethyl 2,2-difluoro-3-hydroxypropanoate | HCID 2758828 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Ethyl 2,2-difluoro-3-tetrahydropyranyloxypropionate | HCID 54421599 | — |
反応手順
Dihydropyrane (2 ml, 22 mmol) was added to a solution of ethyl 2,2-difluoro-3-hydroxypropionate (3.1 g, 20 mmol) and pyridinium p-toluene sulfonate (0.25 g, 1 mmol) in anhydrous dichloromethane (50 ml). The mixture was stirred overnight at room temperature and the desired compound ethyl 2,2-difluoro-3-tetrahydropyranyloxypropionate was obtained by flash chromatography on silica gel (ethyl acetate:hexane; 15:85) (4 g, 80%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05416076 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-cada9db6ab594c27a31aff0a721ade6b |
| 出典メモ | uspto-grants-1995_05 |