Acetic Acid → HCID 23293235、化合物

HRID 365954

反応式

HRID 365954 の反応式
[Br:1]Br.C(O)(=O)C.[CH3:7][C:8]1[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[C:12]([OH:19])[CH:11]=[CH:10][CH:9]=1>O.C(OCC)(=O)C>[Br:1][C:9]1[CH:10]=[CH:11][C:12]([OH:19])=[C:13]([C:8]=1[CH3:7])[C:14]([O:16][CH2:17][CH3:18])=[O:15]

参加物

6

反応物 3

HCID 176Acetic Acid2 回HCID 24408BromineHCID 584222Ethyl 2-hydroxy-6-methylbenzoate

生成物 1

HCID 23293235HCID 23293235、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of bromine (5.05 ml, 0.099 mol) and acetic acid (15 ml) is added to a mixture of ethyl 6-methyl-2-hydroxybenzoate (17.05 g, 0.095 mol), and acetic acid (15 ml) at a temperature of 20° C. The reaction mixture is stirred at room temperature for 1 hour. The reaction mixture is diluted with water and ethyl acetate. The organic phase is washed with water twice, concentrated in vacuo and the residue is purified by flash chromatography (petrol ethers:ethyl acetate, 98:2 v/v) yielding the pure product as a yellow oil, 21.7 g, (88.2%).

後処理

  1. washThe organic phase is washed with water twice
  2. concentrationconcentrated in vacuo
  3. customthe residue is purified by flash chromatography (petrol ethers:ethyl acetate, 98:2 v/v)

出典と根拠

ORDレコード
ord-a7b02d0bff1d45a7a3200b6dadfc077f
出典データセット
uspto-grants-2000_10
特許番号
US06127570

関連ノート

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