化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 3-Bromo-6-hydroxy-2-methylbenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Ethyl 3-bromo-6-hydroxy-2-methylbenzoate | HCID 23293235 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-Bromo-6-hydroxy-2-methylbenzoic acid | HCID 11053451 | — |
反応手順
A mixture of 1A (20.2 g, 0.078 mol), ethanol (150 ml) and an aqueous sodium hydroxide (12 g, 0.3 mol in 100 ml water) is heated under reflux with stirring for 16 hours. The reaction mixture is cooled to room temperature, diluted with water (600 ml) and acidified with concentrated hydrochloric acid. The precipitate is collected and washed with water yielding 18.45 g (100%) white crystals with a melting point of 163-165° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06127570 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-1ca1a3967616418894d2d29c8c92c8a9 |
| 出典メモ | uspto-grants-2000_10 |