Methanol → (3-Bromo-6-hydroxy-2-methylphenyl)(2,3,4-trimethoxy-6-methylphenyl)methanone

HRID 365958ノート

反応式

HRID 365958 の反応式
C([O:4][C:5]1[CH:25]=[CH:24][C:23]([Br:26])=[C:22]([CH3:27])[C:6]=1[C:7]([C:9]1[C:14]([CH3:15])=[CH:13][C:12]([O:16][CH3:17])=[C:11]([O:18][CH3:19])[C:10]=1[O:20][CH3:21])=[O:8])(=O)C.C(=O)([O-])[O-].[K+].[K+].CO>O>[Br:26][C:23]1[CH:24]=[CH:25][C:5]([OH:4])=[C:6]([C:22]=1[CH3:27])[C:7]([C:9]1[C:14]([CH3:15])=[CH:13][C:12]([O:16][CH3:17])=[C:11]([O:18][CH3:19])[C:10]=1[O:20][CH3:21])=[O:8]

参加物

5

反応物 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 109062512-Acetoxy-5-bromo-6,6'-dimethyl-2', 3', 4'-trimethoxy-benzophenone

生成物 1

HCID 10938097(3-Bromo-6-hydroxy-2-methylphenyl)(2,3,4-trimethoxy-6-methylphenyl)methanone

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A mixture of 1D (0.7 g, 1.6 mmol), potassium carbonate (0.7 g), methanol (10 ml) and water (5 ml) is stirred at room temperature for 20 hours. The reaction mixture is poured into water and extracted with diisopropylether. The organic phase is separated and concentrated. The pure product is obtained as a yellow solid, 0.48 g (75.9%), mp. 119-120° C.

後処理

  1. extractionextracted with diisopropylether
  2. customThe organic phase is separated
  3. concentrationconcentrated
  4. customThe pure product is obtained as a yellow solid, 0.48 g (75.9%), mp. 119-120° C.

出典と根拠

ORDレコード
ord-ee76843728674c7b8b3741362ba4a957
出典データセット
uspto-grants-2000_10
特許番号
US06127570

反応ノート

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