化工社化工社 化学情報印刷レポート · 研究参考用
1,3,5-Trichlorobenzene → Ammonia
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,3,5-Trichlorobenzene | HCID 7950 | — |
| 反応物 | 1,3,5-Trifluorobenzene | HCID 9745 | — |
| 反応物 | 3,5-Difluoroaniline | HCID 96595 | — |
| 生成物 | Ammonia | HCID 222 | — |
| 生成物 | 1,3,5-Trifluorobenzene | HCID 9745 | — |
| 生成物 | 3,5-Difluoroaniline | HCID 96595 | — |
反応手順
One embodiment of the present invention relates to the discovery that 3,5-difluoroaniline can be synthesized at high yields and high purity by fluorinating 1,3,5-trichlorobenzene in the presence of a polar solvent to make an intermediate 1,3,5-trifluorobenzene, and then aminating the 1,3,5-trifluorobenzene in the presence of aqueous or anhydrous ammonia to obtain the desired 3,5-difluoroaniline.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06127577 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-4b08970ec16c4bdc8e67712613b25e80 |
| 出典メモ | uspto-grants-2000_10 |