Hydrochloric Acid → 1-(o-Aminophenyl)-4-chloro-1-butanone hydrochloride

HRID 365969

反応式

HRID 365969 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:13])[CH2:9][CH2:10][CH2:11]O.[ClH:14]>O>[ClH:14].[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:13])[CH2:9][CH2:10][CH2:11][Cl:14]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 112061181-(o-Aminophenyl)-4-hydroxy-1-butanone

生成物 1

HCID 232932461-(o-Aminophenyl)-4-chloro-1-butanone hydrochloride収率 73%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 9.3 g (5.1 mmol) of 1-(o-aminophenyl)-4-hydroxy-1-butanone, 26 mL of water and 90 mL of 37% HCl is refluxed for about 6.5 hours, cooled and filtered to afford 8.0 g of 1-(o-aminophenyl)-4-chloro-1-butanone hydrochloride. Extraction of the aqueous mother liquor with methylene chloride gives an additional 1.10 g of the title product for an overall yield of 73% (mp 142-145° C.). The product is identified by NMR and MS analyses.

後処理

  1. temperatureis refluxed for about 6.5 hours
  2. temperaturecooled
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-b8b11781c5314a5195fcb3226aa20638
出典データセット
uspto-grants-2000_10
特許番号
US06127576

関連ノート

読み込み中…