2,4-Difluorobenzaldehyde → 2,4-Difluoro-1-methylbenzene

HRID 365973

反応式

HRID 365973 の反応式
[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH:4]=O.FC1C=C(F)C=CC=1CO>[Ni]>[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH3:4]

参加物

4

反応物 2

HCID 737702,4-DifluorobenzaldehydeHCID 918672,4-Difluorobenzyl alcohol

生成物 1

HCID 679832,4-Difluoro-1-methylbenzene収率 68.6%

試薬・触媒・溶媒 1

HCID 935Nickel触媒

実験手順

DE-A 2,333,849 discloses that 2,4-difluorobenzaldehyde can be converted into 2,4-difluorobenzyl alcohol in a yield of 68.6% by hydrogenation over Raney nickel. Disadvantages of this process are not only the large amount of catalyst (31 g per mol) and the large amount of a solvent (1100 ml per mole) but also the unsatisfactory yield of 68.6%. These factors result in an unsatisfactory space-time yield. The aldehyde used was obtained here from the difficult-to-obtain 2,4-difluorotoluene by side-chain chlorination and subsequent hydrolysis.

後処理

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出典と根拠

ORDレコード
ord-7abb27e4324043f09f8c1963b7bffe45
出典データセット
uspto-grants-2000_10
特許番号
US06127581

関連ノート

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