化工社化工社 化学情報印刷レポート · 研究参考用
Chlorodifluoromethane → 4-difluoromethoxy-pyrazolidine-N,N'-dicarboxylic acid di-tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chlorodifluoromethane | HCID 6372 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Di-tert-butyl 4-hydroxypyrazolidine-1,2-dicarboxylate | HCID 10334299 | — |
| 触媒 | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-difluoromethoxy-pyrazolidine-N,N'-dicarboxylic acid di-tert-butyl ester | HCID 53779472 | 33.3% |
反応手順
0.2 g of tetrabutylammonium fluoride and 5.6 g of potassium hydroxide powder are added to a solution of 6.9 g of 4-hydroxy-pyrazolidine-N,N'-dicarboxylic acid di-tert-butyl ester in 60 ml of tetrahydrofuran. At a maximum of 45° C., 8.0 g of chlorodifluoromethane are introduced. The reaction solution is then filtered, concentrated and purified by means of column chromatography to yield 2.7 g of the desired product, 4-difluoromethoxy-pyrazolidine-N,N'-dicarboxylic acid di-tert-butyl ester, in the form of a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05416065 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-ab3109325d83479eba6f59e9863eaba5 |
| 出典メモ | uspto-grants-1995_05 |