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Triethylamine → 4-(9,10-Dihydro-10-methyl-9-acridinyl)-1-(2,2,2-trichloroethyloxycarbonyl)piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2,2,2-Trichloroethyl chloroformate | HCID 87063 | — |
| 反応物 | 9,10-Dihydro-10-methyl-9-(1-methyl-4-piperidinyl)acridine | HCID 14175799 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 4-(9,10-Dihydro-10-methyl-9-acridinyl)-1-(2,2,2-trichloroethyloxycarbonyl)piperidine | HCID 15289479 | — |
反応手順
Trichloroethyl chloroformate (1.06 mL, 7.7 mmol) is added over a 10 minute period to a solution of 9,10-dihydro-10-methyl-9-(1-methyl-4-piperidinyl)acridine (453 mg, 1.55 mmol) [(Tetrahedron Letters, 29, 5701 (1988)] and triethylamine (649 μl, 4.65 mmol) in 20 mL of dry toluene at 85° C. The reaction is worked up after 30 minutes by extracting with EtOAc and washing with a 10% NaOH solution. The crude product is obtained after the solvent is removed.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05416087 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-9e0dd83f798f4dbe8b7f1a52e3c99f19 |
| 出典メモ | uspto-grants-1995_05 |