Hydromorphone Hydrochloride → Hydromorphone

HRID 366283

反応式

HRID 366283 の反応式
[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3=[CH:8][CH:9]=[C:10]([OH:21])[C:11]4[O:12][C@H:13]5[C:14]([CH2:16][CH2:17][C@@H:18]2[C@:5]5([C:6]=43)[CH2:4][CH2:3]1)=[O:15].Cl>O>[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3=[CH:8][CH:9]=[C:10]([OH:21])[C:11]4[O:12][C@H:13]5[C:14]([CH2:16][CH2:17][C@@H:18]2[C@:5]5([C:6]=43)[CH2:4][CH2:3]1)=[O:15]

参加物

3

反応物 1

HCID 5462347Hydromorphone Hydrochloride

生成物 1

HCID 5284570Hydromorphone

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Hydromorphone beads were prepared by dissolving hydromorphone HCl in water, adding Opadry®, and mixing for about 1 hour, and then spraying onto nu pariel 18/20 beads using a Wurster insert. The resultant coated beads were then overcoated with Opadry® Y-5-1442 light pink (15% w/w). The beads were then overcoated with a aqueous dispersion of Aquacoat® to a 15% weight gain according to Table 15 below:

後処理

  1. additionadding Opadry®
  2. additionmixing for about 1 hour

出典と根拠

ORDレコード
ord-d2a3b43270744e1aac32e5ba82e46434
出典データセット
uspto-grants-2000_10
特許番号
US06129933

関連ノート

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