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4-Toluenesulfonyl chloride → 16-(p-Toluensulfonyloxy)hexadecanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 反応物 | 1,16-Hexadecanediol | HCID 82184 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 16-(p-Toluensulfonyloxy)hexadecanol | HCID 18366472 | — |
反応手順
To a solution of 1.1 g of 1,16-dihydroxyhexadecane in 10 ml of dry pyridine 0.8 g of tosyl chloride was added. After 2 h mixture was concentrated diluted with 20 ml of acetone, 5 g of SiO2 was added and acetone was removed in vacuum. The solid was applied on SiO2 and eluted with pentane-ethyl acetate (2:1) to yield 748 mg (42%) of C-101.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06130037 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-e13d3a98014543ba8b953bfdfb674d24 |
| 出典メモ | uspto-grants-2000_10 |