4-Fluoroaniline → HCID 70255947、化合物
反応式
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.O=[C:10]1[CH2:14][CH2:13][CH2:12][CH:11]1[C:15]#[N:16].[Cl-].[Ca+2].[Cl-]>>[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:10]2[CH2:14][CH2:13][CH2:12][C:11]=2[C:15]#[N:16])=[CH:4][CH:3]=1参加物
4
実験手順
4-Fluoro-aniline (Aldrich Chemicals) (2.3 g, 21 mmol), cyano-ketone (Example 11) (2.2 g, 20 mmol), calcium chloride (2.5 g, 23 mmol) and T.H.F. (30 ml) were heated under reflux for 21 hours. After being allowed to cool, the mixture was filtered and the solvent evaporated. Kugelrohr distillation (160° C., 0.4 mm Hg) gave the product as an off-white powder.
後処理
- temperature(30 ml) were heated
- temperatureunder reflux for 21 hours
- temperatureto cool
- filtrationthe mixture was filtered
- customthe solvent evaporated
- distillationKugelrohr distillation (160° C., 0.4 mm Hg)
出典と根拠
- ORDレコード
- ord-b79fefa60f7d47428fa503d0599f1070
- 出典データセット
- uspto-grants-2000_10
- 特許番号
- US06130228
反応ノート
読み込み中…