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3-Amino-1-(diphenylmethyl)azetidine → 1-(1-Benzhydryl-azetidin-3-ylamino)-3-(2-methyl-benzothiazol-7-yloxy)-propan-2-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Amino-1-(diphenylmethyl)azetidine | HCID 5744546 | — |
| 反応物 | 2-Methyl-7-(oxiranyl-2-ylmethoxy)benzothiazole | HCID 131722120 | — |
| 溶媒 | Dioxan ethanol | HCID 22560076 | — |
| 生成物 | 1-(1-Benzhydryl-azetidin-3-ylamino)-3-(2-methyl-benzothiazol-7-yloxy)-propan-2-ol | HCID 54077942 | — |
反応手順
The title compound was prepared according to Method A from 2-methyl-7-(oxiranyl-2-ylmethoxy)benzothiazole and 3-amino-1-benzhydrylazetidine with dioxane/ethanol (1:1) as the solvent. mp 55° C.; LSIMS m/z 460. The 3-amino-1-benzhydrylazetidine was prepared as described in Preparation 96.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06130217 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-09b7a2c5efbc48d7901f72b7881882cf |
| 出典メモ | uspto-grants-2000_10 |