tert-Butyl chloroacetate → Tert-butyl 5-(biphenyl-4-ylmethyl)-1,1-dioxo-1,2,5-thiadiazolidine-2-acetate

HRID 366477ノート

反応式

HRID 366477 の反応式
ClC1C=CC(N2CCN(S(N)(=O)=O)CC2)=CC=1.Cl[CH2:19][C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21].[C:27]1([C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[CH:32]=[CH:31][C:30]([CH2:33][N:34]2[S:38](=[O:40])(=[O:39])[NH:37][CH2:36][CH2:35]2)=[CH:29][CH:28]=1>>[C:27]1([C:41]2[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=2)[CH:28]=[CH:29][C:30]([CH2:33][N:34]2[S:38](=[O:40])(=[O:39])[N:37]([CH2:19][C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:36][CH2:35]2)=[CH:31][CH:32]=1

参加物

4

反応物 3

HCID 66052tert-Butyl chloroacetateHCID 226156705-(Biphenyl-4-ylmethyl)-1,1-dioxo-1,2,5-thiadiazolidineHCID 22615685[4-(4-Chlorophenyl)piperazine-1-sulfonyl]amine

生成物 1

HCID 54373566Tert-butyl 5-(biphenyl-4-ylmethyl)-1,1-dioxo-1,2,5-thiadiazolidine-2-acetate

実験手順

Proceeding as described in Example 7, Step 2 above, but substituting potassium tert-butoxide and [4-(4-chlorophenyl)piperazine-1-sulfonyl]amine with tert-butyl chloroacetate and 5-(biphenyl-4-ylmethyl)-1,1-dioxo-1,2,5-thiadiazolidine gave tert-butyl 5-(biphenyl-4-ylmethyl)-1,1-dioxo-1,2,5-thiadiazolidine-2-acetate.

出典と根拠

ORDレコード
ord-0c591902d8d048ebae7ec495dd62e600
出典データセット
uspto-grants-2000_10
特許番号
US06130220

反応ノート

読み込み中…