化工社化工社 化学情報印刷レポート · 研究参考用
Phosphorus pentachloride → Pyridine-3-sulfonyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphorus pentachloride | HCID 24819 | — |
| 反応物 | 3-Pyridinesulfonic acid | HCID 69468 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Pyridine-3-sulfonyl chloride | HCID 3164136 | 92% |
反応手順
3-Pyridylsulfonic acid (30 g, 0.188 mole) was added to PCl5 (46.8 g, 0.225 mole), suspended in 150 mL toluene and heated to reflux overnight. The suspension was cooled and concentrated to yield a yellow oil, which was diluted with benzene, filtered through a pad of celite and concentrated to give 30.7 g (92%) of 23-10 as a yellow oil, which was used in the next step without purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05416099 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-bf556213779245328caa8e5257c096ab |
| 出典メモ | uspto-grants-1995_05 |