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3-Bromoaniline → 1-(t-Butyldimethylsiloxy)-4-(3-amino-phenyl)-3-butyne
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Bromoaniline | HCID 11562 | — |
| 反応物 | (But-3-yn-1-yloxy)(tert-butyl)dimethylsilane | HCID 4304567 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Butylamine | HCID 8007 | — |
| 生成物 | 1-(t-Butyldimethylsiloxy)-4-(3-amino-phenyl)-3-butyne | HCID 22225739 | — |
反応手順
A mixture of 1-(t-butyldimethylsilyloxy)-3-butyne (10 mmol) and m-bromoaniline (10 mmol) in n-butylamine (50 mL) under a nitrogen atmosphere is treated with tetrakis(triphenylphosphine)palladium (0) (0.17 g) and then heated to reflux for 18 hr. After removing the solvent in vacuo, the residue is dissolved in CH2Cl2 and washed with saturated NaHCO3. The combined organic solution is dried over magnesium sulfate, filtered and evaporated to give the above described silyl protected adduct.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06130234 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-2bffa424f5384ed486a6d8f0e064a4a9 |
| 出典メモ | uspto-grants-2000_10 |