Methyl 3-bromo-2,4,5-trifluorobenzoate → Methyl 3-cyano-2,4,5-trifluoro-benzoate

HRID 367013ノート

反応式

HRID 367013 の反応式
Br[C:2]1[C:3]([F:14])=[C:4]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:5]([O:7][CH3:8])=[O:6].[Cu](C#N)[C:16]#[N:17]>CN(C)C=O>[C:16]([C:2]1[C:3]([F:14])=[C:4]([CH:9]=[C:10]([F:13])[C:11]=1[F:12])[C:5]([O:7][CH3:8])=[O:6])#[N:17]

参加物

4

反応物 2

HCID 18459836Methyl 3-bromo-2,4,5-trifluorobenzoateHCID 178418260HCID 178418260、化合物

生成物 1

HCID 18417526Methyl 3-cyano-2,4,5-trifluoro-benzoate収率 66.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

269 g of methyl 3-bromo-2,4,5-trifluoro-benzoate and 108 g of copper cyanide are heated to reflux for 5 hours in 400 ml of dimethylformamide. All volatile constituents of the reaction mixture are then removed by distillation in vacuo. The distillate is then fractionated on a column. 133 g of methyl 3-cyano-2,4,5-trifluoro-benzoate of boiling point 88-89° C./0.01 mbar are obtained.

後処理

  1. customAll volatile constituents of the reaction mixture are then removed by distillation in vacuo

出典と根拠

ORDレコード
ord-d705c77f39044b13bb017887475eccd2
出典データセット
uspto-grants-2000_10
特許番号
US06133260

反応ノート

読み込み中…