Acetic Anhydride → Ethyl 2-(2,4-dichloro-3,6-difluorobenzoyl)-3-ethoxyacrylate

HRID 36710ノート

反応式

HRID 36710 の反応式
[Cl:1][C:2]1[C:15]([F:16])=[C:14]([Cl:17])[CH:13]=[C:12]([F:18])[C:3]=1[C:4]([CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].[CH:19](OCC)(OCC)[O:20][CH2:21][CH3:22].C(OC(=O)C)(=O)C>>[Cl:1][C:2]1[C:15]([F:16])=[C:14]([Cl:17])[CH:13]=[C:12]([F:18])[C:3]=1[C:4]([C:6](=[CH:19][O:20][CH2:21][CH3:22])[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5]

参加物

4

反応物 3

HCID 7918Acetic AnhydrideHCID 31214Ethyl orthoformateHCID 15070035Ethyl (2,4-dichloro-3,6-difluorobenzoyl)acetate

生成物 1

HCID 53750212Ethyl 2-(2,4-dichloro-3,6-difluorobenzoyl)-3-ethoxyacrylate

実験手順

13.7 g of ethyl (2,4-dichloro-3,6-difluorobenzoyl)acetate are heated under reflux with 10.25 g of triethyl orthoformate and 11.8 g of acetic anhydride for 2 hours. The mixture is then concentrated in vacuo up to a bath temperature of 140° C. and 15.7 g of ethyl 2-(2,4-dichloro-3,6-difluorobenzoyl)-3-ethoxy-acrylate are obtained as an oil, nD25 : 1.5302.

後処理

  1. concentrationThe mixture is then concentrated in vacuo up to a bath temperature of 140° C. and 15.7 g of ethyl 2-(2,4-dichloro-3,6-difluorobenzoyl)-3-ethoxy-acrylate
  2. customare obtained as an oil, nD25 : 1.5302

出典と根拠

ORDレコード
ord-12d109b8572e454597f795a576fdd579
出典データセット
uspto-grants-1995_05
特許番号
US05416096

反応ノート

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