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Ammonium thiocyanate → 2-[N-(4-bromophenyl)-N-ethylamino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium thiocyanate | HCID 15666 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 2-Chloronicotinic acid | HCID 76258 | — |
| 反応物 | 4-bromo-N-ethylaniline | HCID 11745656 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-[N-(4-bromophenyl)-N-ethylamino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one | HCID 23287574 | 75.3% |
反応手順
The reaction procedure of Example 57 was followed except that 1.203 g (7.63 mmol) of 2-chloronicotinic acid, 15 ml of thionyl chloride, two droplets of DMF, 639 mg of ammonium thiocyanate, 15 ml of acetone, 1.53 g of N-ethyl-4-bromoaniline and 10 ml of acetone were used. The product was then recrystallized from ethanol to obtain 2.08 g of 2-[N-(4-bromophenyl)-N-ethylamino)-4H-pyrido[3,2-e]-1,3-thiazin-4-one.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06133258 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-fa28f574ce1144d4a70656d542ed6a6a |
| 出典メモ | uspto-grants-2000_10 |