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4-Chloro-4'-nitrobenzophenone → 4-Amino-4'-chlorobenzophenone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloro-4'-nitrobenzophenone | HCID 347771 | — |
| 触媒 | Platinum oxide (PtO) | HCID 82844 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-Amino-4'-chlorobenzophenone | HCID 3528706 | 79.2% |
反応手順
A suspension of 14.4g (54.8 mmol) of 4-chloro-4'-nitrobenzophenone and 66.9 mg, (0.5 mole %) of platinum oxide was stirred under hydrogen in 300 ml of ethanol for 2 hours The mixture was filtered, evaporated and purified by flash column chromatography (2-8% EtOAc/CH2C12) to obtain 10.05 g (72%) of the desired product as a yellow solid. 1H nmr (CDCl3) δ4.16 (2H, br s), 6.67 (2H, d), 7.43 (2H, d), 7.68 (2H, d), 7.69 (2H, d).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05416112 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-53781cf8028d4ddc9316d7676db2b9e0 |
| 出典メモ | uspto-grants-1995_05 |