4-Chloro-4'-nitrobenzophenone → 4-Amino-4'-chlorobenzophenone

HRID 36719

反応式

HRID 36719 の反応式
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1>C(O)C.[Pt]=O>[NH2:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]([C:5]2[CH:17]=[CH:18][C:2]([Cl:1])=[CH:3][CH:4]=2)=[O:7])=[CH:9][CH:10]=1

参加物

4

反応物 1

HCID 3477714-Chloro-4'-nitrobenzophenone

生成物 1

HCID 35287064-Amino-4'-chlorobenzophenone収率 79.2%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒

実験手順

A suspension of 14.4g (54.8 mmol) of 4-chloro-4'-nitrobenzophenone and 66.9 mg, (0.5 mole %) of platinum oxide was stirred under hydrogen in 300 ml of ethanol for 2 hours The mixture was filtered, evaporated and purified by flash column chromatography (2-8% EtOAc/CH2C12) to obtain 10.05 g (72%) of the desired product as a yellow solid. 1H nmr (CDCl3) δ4.16 (2H, br s), 6.67 (2H, d), 7.43 (2H, d), 7.68 (2H, d), 7.69 (2H, d).

後処理

  1. filtrationwas filtered
  2. customevaporated
  3. custompurified by flash column chromatography (2-8% EtOAc/CH2C12)

出典と根拠

ORDレコード
ord-53781cf8028d4ddc9316d7676db2b9e0
出典データセット
uspto-grants-1995_05
特許番号
US05416112

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