Ammonium thiocyanate → HCID 86755945、化合物

HRID 367205ノート

反応式

HRID 367205 の反応式
Cl[C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[S-:11][C:12]#[N:13].[NH4+].[CH3:15][NH:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:19][CH:18]=1>CC(C)=O>[CH3:15][N:16]([C:17]1[CH:18]=[CH:19][C:20]([CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:21][CH:22]=1)[C:12]1[S:11][C:2]2[N:10]=[CH:9][CH:8]=[CH:7][C:3]=2[C:4](=[O:5])[N:13]=1

参加物

5

反応物 3

HCID 15666Ammonium thiocyanateHCID 27745412-Chloronicotinoyl chlorideHCID 11550151N-methyl-4-ethoxycarbonylmethylaniline

生成物 1

HCID 86755945HCID 86755945、化合物収率 49.7%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

The reaction procedure of Example 102 was followed except that 1.256 g of 2-chloronicotinoyl chloride, 543 mg of ammonium thiocyanate, 1.379 g of ethyl [4-(methylamino)phenyl]acetate and 24 ml of acetone were used. The product was then recrystallized from ethanol to obtain 1.26 g of ethyl [4-[N-methyl-N-(4-oxo-4H-pyrido[3,2-e]-1,3-thiazin-2-yl)amino]phenyl]acetate.

後処理

  1. customThe reaction procedure of Example 102
  2. customThe product was then recrystallized from ethanol

出典と根拠

ORDレコード
ord-50ec23e77a3c43d7ac15eedbbc003ae6
出典データセット
uspto-grants-2000_10
特許番号
US06133258

反応ノート

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