HCID 19937697、化合物 → 2-Phenyl-1-tetralone

HRID 36740ノート

反応式

HRID 36740 の反応式
[CH2:1]([Mg]Br)[CH3:2].Cl[CH:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]1(C1C=CC=CC=1)[OH:16]>C1C=CC=CC=1>[C:2]1([CH:6]2[CH2:15][CH2:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]2=[O:16])[CH:1]=[CH:8][CH:7]=[CH:6][CH:15]=1

参加物

4

反応物 2

HCID 19937697HCID 19937697、化合物HCID 178418443HCID 178418443、化合物

生成物 1

HCID 3483282-Phenyl-1-tetralone収率 187.8%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

反応条件

温度
0 °C

実験手順

Step C Add ethylmagnesium bromide (1.76 mL, 5.27 mmol, M in) dropwise to a 0° C. solution of 2-chloro-1-phenyl-1,2,3,4-tetrahydronaphth-1-ol (1.36 g, 5.27 mmol) in dry benzene (20 mL). Stir the solution at 0° C. for 30 min and heat to reflux for 5 hours. Cool the mixture to room temperature and quench with saturated NH4Cl (aqueous). Extract with ether, combine the ethereal extracts, wash with water and brine, dry over Na2SO4 and concentrate to provide 1.1 g (94%) of the title compound.

後処理

  1. temperatureheat
  2. temperatureto reflux for 5 hours
  3. temperatureCool the mixture to room temperature
  4. customquench with saturated NH4Cl (aqueous)
  5. extractionExtract with ether
  6. washwash with water and brine
  7. dry with materialdry over Na2SO4
  8. concentrationconcentrate

出典と根拠

ORDレコード
ord-a1ff33aa23844205b97f4101a245f871
出典データセット
uspto-grants-1995_05
特許番号
US05416118

反応ノート

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