Potassium Hydroxide → 2-Benzylacrylic Acid

HRID 36745

反応式

HRID 36745 の反応式
[CH2:1]=[C:2]([CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]([O:5]CC)=[O:4].[OH-].[K+]>CO>[CH2:1]=[C:2]([CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]([OH:5])=[O:4]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 11084648Ethyl 2-benzylacrylate

生成物 1

HCID 3035712-Benzylacrylic Acid収率 71%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The ethyl α-methylenebenzenepropanoate of Step 8 (4.6 g, 24.3 mmol) was dissolved in methanol (12 mL) and then reacted with 2N potassium hydroxide (24 mL) solution. The mixture was stirred at room temperature for 4 hours and concentrated by evaporation. The residue was diluted with water and washed with ether. The aqueous layer was acidified to pH 2 with 1N HCl, and then extracted with ethyl acetate. The extracts were dried (MgSO4) and evaporated to give the title compound as colorless oil (2.8 g, 66% yield). 1H NMR: 300 MHz spectrum consistent with proposed structure.

後処理

  1. concentrationconcentrated by evaporation
  2. additionThe residue was diluted with water
  3. washwashed with ether
  4. extractionextracted with ethyl acetate
  5. dry with materialThe extracts were dried (MgSO4)
  6. customevaporated

出典と根拠

ORDレコード
ord-7003251b1fd440dababdec12f1aa32e2
出典データセット
uspto-grants-1995_05
特許番号
US05416119

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