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Hydrochloric Acid → 3,4-Dihydro-4-oxo-2-(pyridin-3-yl)-6-methylthieno[2,3-d]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1,4-Dioxane | HCID 31275 | — |
| 反応物 | Ethyl 2-Amino-5-methylthiophene-3-carboxylate | HCID 4062885 | — |
| 反応物 | 3-Cyanopyrimidine | HCID 23287905 | — |
| 生成物 | 3,4-Dihydro-4-oxo-2-(pyridin-3-yl)-6-methylthieno[2,3-d]pyrimidine | HCID 23287906 | — |
反応手順
2-Amino-5-methyl-3-ethoxycarbonyl-thiophene (5 g) is solved with 3-cyanopyrimidine (2.7 g) in dioxane (40 ml). Then gaseous HCl is conducted through the solution for 5 hours. The usual workup yields 3,4-dihydro-4-oxo-2-(pyridin-3-yl)-6-methyl-thieno-[2,3-d]-pyrimidine (6 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06133271 |
| 出典データセット | uspto-grants-2000_10 |
| ORD ID | ord-d17f1305f2b34cccbcbb823dc03f1a12 |
| 出典メモ | uspto-grants-2000_10 |