3-Cyanopyridine → 4-Chloro-2-(pyridin-3-yl)-6-nitro-thieno-[2,3-d]-pyrimidine

反応式

[C:1]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=1)#[N:2].[NH2:9][C:10]1[S:11][C:12]([N+:20]([O-:22])=[O:21])=[CH:13][C:14]=1[C:15](OCC)=O.O=P(Cl)(Cl)[Cl:25]>>[Cl:25][C:15]1[C:14]2[CH:13]=[C:12]([N+:20]([O-:22])=[O:21])[S:11][C:10]=2[N:9]=[C:1]([C:3]2[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=2)[N:2]=1

参加物

反応物 3

HCID 793-Cyanopyridine

HCID 24813Phosphorus oxychloride

HCID 27376083-Thiophenecarboxylic acid, 2-amino-5-nitro-, ethyl ester

生成物 1

HCID 184599734-Chloro-2-(pyridin-3-yl)-6-nitro-thieno-[2,3-d]-pyrimidine

実験手順

With the procedure of Example 477, the reaction of 3-cyanopyridine and 2-amino-5-nitro-3-ethoxycarbonyl-thiophene, and the subsequent reaction with POCl3 yields 4-chloro-2-(pyridin-3-yl)-6-nitro-thieno-[2,3-d]-pyrimidine

出典と根拠

ORDレコード: ord-6a43930355984acea27f83bf028078f6
出典データセット: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06133271

反応ノート

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